PD-1/PD-L1 is an important signaling pathway in the adaptive immune system. The CD47/SIRPa signaling pathway is a crucial "do not eat me" signal for innate immunity. This study evaluated the anti-tumor mechanism of IMM2520 in vitro and in vivo. IMM2520 was generated using the "mab-trap" platform. IMM2520 showed high affinity to PD-L1 and relatively lower affinity to CD47, displaying ...

CD47 is overexpressed on the surface of many types of cancer cells, including T-cell acute lymphoblastic leukemia (T-ALL) cells. In this study, we have developed a diphtheria toxin (DT)-based bivalent anti-human CD47 immunotoxin (bi-CD47-IT) for the targeted therapy of CD47 + cancers using a unique DT-resistant yeast Pichia pastoris expression system.